The two astronauts were sent to ISS from the historic launch Pad 39A.
United States: A SpaceX Falcon 9 rocket carrying two veteran NASA astronauts lifted off on Saturday on an historic first private crewed flight into space.
The two-stage Falcon 9 rocket with astronauts Robert Behnken and Douglas Hurley aboard blasted off smoothly in a cloud of orange flames and smoke from Launch Pad 39A at Florida's Kennedy Space Center for the 19-hour voyage to the International Space Station.
The first booster stage of the rocket separated cleanly and landed upright on a barge off the Atlantic coast.
The second stage also separated smoothly, sending the astronauts in the Crew Dragon capsule on their way to the space station orbiting some 250 miles (450 kilometers) above the Earth.
The first crewed flight from US soil since the space shuttle program ended in 2011 had originally been scheduled for Wednesday but was delayed because of weather conditions, which also remained uncertain on Saturday right up until liftoff at 3:22 pm (1922 GMT).
President Donald Trump flew to Florida aboard Air Force One to watch the launch and described it as "really something special."
"Real talent, real genius, nobody does it like us," Trump said.
Here are the Highlights of the SpaceX crewed mission launch:
SpaceX Dragon Capsule Successfully Reaches Low Earth Orbit, Says TrumpUS President Donald Trump on Saturday (local time) said that the SpaceX Dragon Capsule has successfully reached low Earth orbit and the two NASA astronauts are safe and sound.
"I am thrilled to announce that the SpaceX Dragon Capsule has successfully reached low Earth orbit, and our astronauts are safe and sound. With this launch, the decades of lost years and little action are officially over. A new age of American ambition has begun," Trump said at the Kennedy Space Center here, where SpaceX's Crew Dragon spacecraft successfully lifted off.
You Did It: US Vice-President Mike Pence Offers Congratulations After Successful SpaceX Crewed Mission Lift Off
Crew Dragon on correct trajectory to reach space station: SpaceX
US President Donald Trump on SpaceX launch: "It's incredible"
First booster stage separates from SpaceX rocket, news agency AFP reported.
US President Donald Trump arrives at Kennedy Space Center for historic SpaceX launch, news agency AFP reported.
SpaceX launch director gives green light to fuel rocket, news agency AFP reported.
SpaceX Rocket Ready To Launch