The compact size of the 600D reduces the area of the hand grip, making it less than idea for people with big hands. (Pictured: Canon 40D on the left, Canon 600D on the right)
The flash on the 600D rises a little higher than normal, to prevent a shadow due to shooting with long lenses. (Pictured: Canon 40D on the left, Canon 600D on the right)
The control interface on the back is totally different on the Canon 600D as compared to the higher grade bodies. (Pictured: Canon 40D on the left, Canon 600D on the right)