Patricia Dagorn, 57, is charged with the fatal poisoning of two men found dead in 2011 on the Cote d'Azur and the drugging of two others. Prosecutors say she attempted to enrich herself by seducing older men she met mostly through a dating agency.
Dagorn is already serving a five-year prison term for theft, fraud and sequestration involving an octogenarian in the French Alps in 2012 who had agreed to let her live with him in exchange for sexual relations.
She was brought into the dock looking dishevelled in an oversize black-and-read tracksuit.
One of the men she is accused of trying to poison, 91-year-old widower Robert Vaux, will take the stand this week to testify against her.
"She was like a ray of sunshine in winter. When you are with a younger woman you know it won't last but you don't deny yourself the moment unless you're a masochist," Vaux, a former sailor, told reporters at the courthouse on Monday.
Police had already suspected Dagorn after the body of Michel Kneffel, a man in his 60s with whom she had been living at a residential hotel in Nice, was discovered in July 2011.
No charges were filed at the time, but the investigation was reopened the following year after police found vials of Valium and personal documents belonging to about a dozen different men among her belongings.
The documents included IDs, bank account details and health insurance cards.
Investigators then followed the trail to another suspected murder case, that of Francesco Filippone, 85, whose body was found in his bathtub in an advanced state of decomposition in Mouans-Sartoux, outside Cannes, in February 2011.
Dagorn had earlier cashed a cheque from Filippone for 21,000 euros ($25,600), money which she said was a gift to help her open a jewellery shop.
"She denies the charges against her in their entirety, including the thefts," said one of her lawyers, Georges Rimondi.
On day one of the trial, Dagorn's lawyers attempted to undermine parts of the prosecution case.
Did she really have a will drawn up for Filippone?
"We haven't found one", an investigator giving evidence admitted.
"She is eager to explain herself," said her other lawyer, Cedric Huissoud, adding that she had suffered during her years in prison.
'Quick and easy money'
Police now think Dagorn may have met at least 20 men, after arriving on the French Riviera in 2011, mainly via a matchmaking agency.
In most of the cases she allegedly asked the men for money or to name her in their wills, or she stole documents from them, while a few were accused of rape.
Vaux, comfortably retired but lonely since the death of his wife, brought Dagorn to live with him in early 2012 in the coastal town of Frejus.
When he was at his lowest ebb, Dagorn wrote to his solicitor, asking to be written into his will, according to Vaux.
He and another man whom Dagorn is accused of trying to poison, Ange Pisciotta, 82, have joined the case as civil plaintiffs.
Both men are expected to take the witness stand on Tuesday.
Dagorn, who has a law degree, had already been handed a one-year suspended prison term in a case involving her ex-husband who was found guilty of fraud.
In 2013, her youngest son told a local newspaper that he was not surprised by the accusations against his mother.
"She has always been obsessed with quick and easy money," the son, identified only as Guilhem, told Nice Matin daily.
(Except for the headline, this story has not been edited by NDTV staff and is published from a syndicated feed.)
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