"The train was en route from the northeastern city of Mashhad to Tehran. So far 10 passengers have been killed and dozens wounded," the semi-official Fars news agency reported. "The death toll is expected to rise."
A local official said the train carried 340 passengers.
State television said the cause of the crash was under investigation by authorities.
In 2004, a runaway train laden with fuel and fertilizers derailed in northeastern Khorasan province, exploded and burst into flames, killing about 300 people.
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