Atlanta Fed chair Raphael Bostin, too, talked up the prospect of a December rate hike.
"Fed chair Janet Yellen was the highlight though," said Chris Weston, Melbourne-based Chief Market Strategist, IG.
"Without going into the speech in any depth, the wash-up is the comments were very much aligned with the recent (Fed) statement, but throw further weight that a December hike is on the cards."
Investors lifted the probability of a rate hike in December to 78 per cent, from 72 per cent late last week.
That sent the dollar to its highest level since August 31 against a basket of currencies and was last holding at 92.966.
The market is now waiting to hear from US President Donald Trump on his tax reform plans as he remains under pressure to produce a legislative victory with the collapse of the latest Republican push to repeal Obamacare.
The mood was less upbeat elsewhere, with MSCI's broadest index of Asia-Pacific shares outside Japan off 0.1 per cent at three-week lows following bellicose statements by Mr Trump and North Korean leader Kim Jong Un.
Mr Trump warned North Korea on Tuesday that any US military option would be "devastating" for Pyongyang, but said the use of force was not Washington's first option to deal with the country's ballistic and nuclear weapons programme.
Even a softer yen could not stop Japan's Nikkei slipping 0.5 per cent, while Australia's main index eased 0.1 per cent.
Wall Street was barely changed, with the Dow down 0.05 per cent, while the S&P 500 added 0.01 per cent and the Nasdaq 0.15 per cent.
The tech sector gained 0.4 per cent, with Apple shares rising 1.7 per cent after four sessions of declines.
The pan-European FTSEurofirst 300 index had ended flat at 1,509.63. Nestle shares climbed 1.8 per cent as the world's largest packaged food company set a profit margin target for the first time.
In currencies, the euro held at more than one-month lows at $1.1781 as investors faced months of political horse trading in Germany before a new government could be formed.
The dollar stood near a two-and-a-half-month high on the yen at 112.27 helped by rising US Treasury yields.
The yield on benchmark 10-year Treasury notes was up at 2.24 per cent after rising 2 basis points overnight.
The two-year yield , which rises with traders' expectations of higher Fed fund rates, touched 1.467 percent, the highest since October 2008.
The advancing greenback pulled commodities priced in dollars lower. Spot gold stood near one-month lows and was last trading at $1,293.21, while copper touched the lowest since mid-August.
Crude oil prices popped up early Wednesday after the weekly API inventory report showed a 761,000 barrel build-up in crude inventories, which suggests downside risks to the consensus estimate of a 2.52 million barrel build in an official report due later in the day.
US crude firmed 22 cents to $52.10 per barrel, while Brent added 19 cents to $58.63.