Concerns over the prospects for a massive U.S. tax cut also showed no sign of abating as two Republican lawmakers on Wednesday criticised the Senate's latest proposal.
MSCI's broadest index of Asia-Pacific shares outside Japan <.MIAPJ0000PUS> inched up 0.1 percent in early trade, while Australian stocks <.AXJO> were a fraction weaker.
Japan's Nikkei <.N225> dithered either side of flat, while EMini futures for the S&P 500 eased 0.03 percent.
Wall Street had been weighed by a retreat in the S&P 500 energy sector which suffered a four-day decline of 4 percent, its weakest such period in 14 months.
The Dow <.DJI> fell 0.59 percent, while the S&P 500 <.SPX> lost 0.55 percent and the Nasdaq <.IXIC> 0.47 percent.
The decline came despite mostly upbeat economic news with core U.S. inflation edging higher and retail sales beating forecasts in a positive sign for growth.
Yet that strength also added to risks that the Federal Reserve would not only hike in December, which is now almost fully priced, but several times next year as well.
That outlook promises to push short-term Treasury yields up further from the current nine-year peaks.
Investors also suspect this tightening will slow the economy and stop inflation ever getting to the Fed's 2 percent target, pulling down longer-term yields .
As a result the gap between two- and 10-year yield has shrunk to 64 basis points, down from 98 basis points four months ago and the thinnest premium since late 2007.
"Whether it is the flattest yield curve in a decade, and what that has historically signalled for future growth, the recent troubles in high-yielding credit or lingering geopolitical tensions, it is not entirely clear what has markets spooked," ANZ analysts wrote in a note.
"But it is a reminder that even though the global economy is experiencing its most broad-based upswing in years, there are enough issues out there to keep investors on their toes."
The upswell of risk aversion benefited the Japanese yen as a traditional safe haven. The dollar was stuck at 112.81 yen having sunk as deep as 112.47 overnight.
Against a basket of currencies, the dollar <.DXY> was up 0.04 percent at 93.848. The euro was down 0.08 percent at $1.1784 , after touching a one-month top of $1.1860 on Wednesday.
Doubts that the latest round of talks to overhaul the North American Free Trade Agreement would make much headway in the face of tough U.S. demands saw Mexico's peso sink to an eight-month low.
In commodity markets, gold followed the U.S. dollar too and for and was last up 0.01 percent at $1,278.87. It reached $1,289.09 overnight, the highest since Oct. 20.
Oil prices were under pressure after the U.S. government reported an unexpected increase in crude and gasoline stockpiles. [O/R]
They had already lost ground to this week's International Energy Agency (IEA) outlook for slower growth in global crude demand.
U.S. crude dipped 4 cents in early Asia to $55.29 a barrel. Brent crude futures had settled off 34 cents at $61.87.