Splashing on its front page a picture of the 76-year-old in his simple white robes, the magazine said his words and actions were "heavier than boulders."
"The first 100 days of his pontificate have already propelled him to the top of the list of world leaders who are making history," said Vanity Fair Italy, adding: "The revolution continues."
The magazine also published interviews with five celebrities, including British pop star Elton John and Italian singer Andrea Bocelli, who paid homage to the Argentinean pope.
John said Francis was "a miracle of humility in an age of vanity."
"I hope he manages to get his message even further, to the most marginalised in society, to those communities which ... desperately need his love. I am thinking for example of homosexuals," added the openly gay pop icon.
For his part, Bocelli said: "Pope Francis is truly a gift from God to his Church which has been tortured and crushed by the forces of evil."