The president and Republican challenger Mitt Romney rushed not only to respond to the killings, but to distance themselves from a campaign that has become increasingly petty and bitter. Mr Obama limited his campaign appearance in Fort Myers to remarks of less than eight minutes, devoted exclusively to the tragedy.
"It reminds us of all the ways that we are united as one American family," he said. He paused at one point to ask for a moment of prayer that lasted 20 seconds. A baby could be heard crying during it.
Mr Obama cancelled a second appearance scheduled near Orlando, Florida, and was returning to Washington. Mr Romney, too, was to address the matter at a previously scheduled campaign event in New Hampshire. He cancelled some media interviews. Both candidates moved to pull ads against each other airing in Colorado.
Mr Obama was notified at dawn at his hotel near West Palm Beach, Florida, by his counterterrorism adviser, John Brennan. The White House said there was no apparent connection to terrorism.
"Our time here is limited, and it is precious," Mr Obama told supporters in Fort Myers. "What matters at the end of the day is not the small things. It's not the trivial things which consume us and our daily lives. Ultimately, it's how we choose to treat one another, and how we love one another. It's what we do on a daily basis to give our lives meaning and to give our lives purpose."
Mr Romney, in a written statement, said: "We are praying for the families and loved ones of the victims during this time of deep shock and immense grief. We expect that the person responsible for this terrible crime will be quickly brought to justice."
The assault by apparently one shooter killed 12 people and injured at least 50 others in one of the deadliest mass shootings in recent U.S. history.
The enormity and horror of the incident immediately injected a new tone to the campaign, essentially demanding that both candidates for the time halt politics and attend to the nation's shock at the tragedy.
Mr Obama sought to temper the campaign spirit of those at his event to fit the mood of the day. He thanked his supporters and said he had looked forward to talking about the differences between Romney and him, saying instead: "This, I think, is a day for prayer and reflection."
Nevertheless, as the end of this remarks about a nation that supports its own and appreciates its blessings, his supporters added a political touch by chanting "Four more years!"
It remained to be seen whether the episode would inject the volatile issue of gun rights - an issue largely missing throughout the months of campaigning so far - into the election debate.
New York Mayor Michael Bloomberg, in a radio interview, admonished both the president and his challenger to forcefully address gun violence.
"You know, soothing words are nice, but maybe it's time that the two people who want to be president of the United States stand up and tell us what they are going to do about it, because this is obviously a problem across the country," he said.
Mr Obama said he viewed the moment through the eyes of a parent. He and his wife have daughters who turned 14 and 11 this year.
"What if Malia and Sasha had been in the theatre?" he asked. "Michelle and I will be fortunate enough to hug our girls a little tighter tonight, and I'm sure you will do the same with your children. But for those parents who may not be so lucky, we have to embrace them and let them know we will be there for them as a nation."
The shooting brought a halt to political events around the country.
Many were cancelled or postponed Friday, from Senate Republican Leader Mitch McConnell's news conference on Capitol Hill to a Democratic event in Reno, Nevada, on funding for an alert system for missing children. Vice President Joe Biden cancelled a fundraiser in Texas and first lady Michelle Obama did the same for planned campaign events in Virginia. Mr Romney's wife, Ann, called off her scheduled event in Michigan.
The tragedy inspired unifying statements, rather than partisan pronouncements, from the nation's leaders.
"I join President Obama, and every American, in sending my thoughts and prayers to the victims of this awful tragedy," said House Speaker John Boehner, R-Ohio. "We will all stand with them, as one nation, in the days ahead."
"The thoughts and prayers of all members of Congress are with Coloradans this morning," said House Democratic Leader Nancy Pelosi, D-Calif.
In Fort Myers, there was none of the customary music to usher the president out. People seemed sad as they left.
Diane Buckley of Fort Myers said, "I liked that someone in a position of leadership can be as emotional as that and take a moment to value the people we love and to reach out to others."