Don Gorske was honoured after reaching the meaty milestone during a ceremony at a McDonald's in his hometown of Fond du Lac.
Surely McDonald's most loyal customer, Guinness World Records recognised Gorske's feat three years and 2,000 Big Macs ago, and the 59-year-old says he has no desire to stop.
"I plan on eating Big Macs until I die," he said.
The sign beneath the golden arches on Tuesday read "Congrats Don Gorske 25,000 Big Macs."
Before he ate No. 25,000, he showed dozens of onlookers many of the different styles of cartons he has collected over the years and other Big Mac-related stories.
Before biting into the sandwich, he said, "It's been seven years since 20,000. Same thing goes this year folks. You can't have the carton and it still takes me 16 bites for me to finish a Big Mac."
The crowd erupted into applause.
Gorske, who appeared in the 2004 documentary "Super Size Me," which examined the fast food industry, looks nothing like one might expect of a fast food junkie.
He's trim and walks regularly for exercise, and he attributes his build to being "hyperactive."
He said he was recently given a clean bill of health and that his cholesterol is low.
Gorske's obsession with the burger - two all-beef patties, special sauce, lettuce, cheese, pickles, onions on a sesame seed bun, for those not familiar with the once-ubiquitous ads - started on May 17, 1972, when he bought three Big Macs to celebrate the purchase of a new car.