"Only change is constant. With change, we change, finally on Twitter," said the first message of the RJD chief on his account, twitter.com/laluprasadrjd.
"Let us all work together towards a common goal for a better future," said another message.
Known for his earthy style and comments, Mr Prasad has drawn 68 followers with the start of the account yesterday.
Mr Prasad's entry on social media has been radical considering his famed comment "Ye IT YT kya hota hain" (what is this IT (Information Technology)).
Besides BJP's Prime Ministerial candidate Narendra Modi, Twitter is being used by many other leaders like LK Advani, Sushma Swaraj, Digvijay Singh and Arun Jaitley.
Former Bihar Deputy Chief Minister Sushil Kumar Modi has also been bombarding comments on his Twitter account.
Twitter has not found favour with Bihar Chief Minister Nitish Kumar so far.