Doctors said she died of severe organ failure. Her parents were by her side. "They bore the entire process with a great deal of fortitude and a great deal of courage," said TCA Raghavan, the Indian High Commissioner to Singapore.
Mr Raghavan was present in hospital when the student died.
The young woman, who was brutally gang-raped by six men in a moving bus in Delhi on December 16, died at 4.45 am local time (2.15 am IST) after battling severe injuries for 13 days.
Her body has been taken in a police van from the super-speciality hospital where she was treated, to the Singapore General Hospital. Some formalities are expected to be completed there, before her parents fly back with her body to India later in the day.
Singapore has a big Indian population and special prayers had been organised at a temple in an area known as Little India.