The man was admitted to Ram Manohar Lohia hospital three days back in a serious condition, hospital sources said.
RML Hospital is one of the 23 designated hospitals identified by the Delhi government for treatment of the ailment.
With today's death, the number of people who have died due to swine flu has increased to five. Meanwhile, 47 fresh cases of swine flu were detected on Thursday, taking the total number to 253.
Delhi Health Minister A K Walia reviewed the situation with top officials of his department and issued direction to them to monitor the situation constantly.
He expressed hope that with the rise in temperature and lowering of humidity, the number of cases will start coming down.
Mr Walia said the government has adequate stock of medicine to offer treatment to swine flu patients.
The Health Minister asked the people to maintain high standard of personal hygiene to prevent the disease.